Lyme disease is a bacterial illness that is transmitted through infected tick bites.
Some symptoms of early stages are headaches, flu-like symptoms, joint pain, fatigue and in some instances, rashes, but symptoms in later stages can be much more serious, including paralysis and neurological problems.
Schumer is among many celebrities who have revealed they have Lyme disease, including Bella Hadid, her mother Yolanda Hadid, Justin Bieber, Avril Lavigne and Shania Twain.
The star and her husband Chris Fischer have decided that if they wanted another baby, pregnancy was out of the question for them.
“We did IVF and IVF was really tough on me,” Schumer said on Sunday Today with Willie Geist.
“I don’t think I could ever do IVF again.
“I decided that I can’t be pregnant ever again. We thought about a surrogate but I think we’re going to hold off for right now.”
More of her pregnancy struggles were documented in the docuseries Expecting Amy, available to stream on Binge, which follows the I Feel Pretty star as she embarks on a tour while pregnant with her son.
One of her biggest struggles she experienced was a severe form of morning sickness called hyperemesis gravidarum.