On Thursday night, Mr Biden will hold a town hall style meeting aired by ABC, while Mr Trump’s version will feature on NBC.
The NBC version will feature a conversation between Mr Trump and a group of Florida voters moderated by Savannah Guthrie.
The network said it would be held outside, with social distancing in place and the audience will be required to wear masks, with every staffer on site tested for the virus.
The station said it had also been assured by Dr. Clifford Lane, Clinical Director at the National Institutes of Health, and Dr Anthony Fauci, who said they have analysed Mr Trump’s medical data and found he is “not shedding infectious virus.”
The ABC event featuring Mr Biden will be hosted by anchor George Stephanopoulos and take place in Philadelphia.
The first debate took place on 29 September just days before the President tested positive for COVID-19.
The two men constantly interrupted one another in the cantankerous exchange that led the Commission to change the rules to allow for a “more orderly discussion of the issues”.