Totality is reached at 10:16 (17:16 GMT; 18:16 BST), and, assuming none of the region's famous coastal fogs are in attendance, people will get one minute and 59 seconds of full darkness.
The Moon's shadow then races across the continent through 13 more states (less than two square kilometres of the extreme southwest of Iowa is in the path) - a journey that will take roughly 90 minutes.
The place that will experience the longest period of totality (2 mins, 40 sec) is about 10km south of the city of Carbondale, Illinois.
The last region in the path of deepest shadow is South Carolina.
The Atlantic coastal city of Charleston experiences its eclipse at 14:47 local time (18:47 GMT; 19:47 BST).
It is around this time that Europeans will be catching their partial view of the event.
Ireland, Northern Ireland, northern England and Scotland see a brief partial eclipse.
In Belfast, for example, this partial starts at 19:37 BST and ends at 20:23 BST.
Southern England sees the Moon start to take a chunk out of the Sun just as it goes over the horizon.
Skywatchers will want to make for high ground and pray that any cloud clears just at the right moment.