The actress has been cast in Season 2 of "Sick Note," a Sky 1 comedy starring Rupert Grint and Nick Frost.
Grint plays Daniel Glass, who the network describes as "a compulsive liar stuck in a failing relationship and dead-end insurance job, under the thumb of irrepressible boss Kenny West (played by Don Johnson)."
Things really take off when Daniel is wrongly diagnosed with a terminal illness by his inept doctor (played by Nick Frost), who convinces him to play along with the misdiagnosis.
Lohan will star as Katerina West, the daughter of Daniel's boss.
On Monday, Lohan tweeted a picture with her new co-stars.
"Jokes with Rupert Grint and @nickjfrost on set of my new show 'Sick Note,'" she wrote in the tweet.